Sheep gene mapping by somatic cell hybridization
نویسندگان
چکیده
منابع مشابه
Complementation of gene deletions by cell hybridization.
Overlapping deletions in chromosome 7 of the mouse are responsible for activity deficiencies of various liver-specific enzymes, including tyrosine aminotransferase (TAT). In an effort to elucidate the nature and type of action of the deleted genes, somatic cell hybridization experiments were carried out. Enzyme-deficient liver cells of homozygous mutant mice or normal liver cells of control new...
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Glycerol-3-phosphate acyltransferase catalyzes the first step of glycerolipid biosynthesis. It plays a key role in the regulation of cellular triacylglycerol and phospholipid levels. There are two isoforms of glycerol-3-phosphate acyltransferase in mammals, a mitochondrial and a cytosolic form. The mitochondrial form (GPAM) prefers saturated fatty acyl-CoA as a substrate, whereas the cytosolic ...
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FUS1 is a candidate tumor suppressor gene organized in a 370 kb region which contains a set of 19 genes. The human FUS1 genomic sequence spans 3.3 kb containing 3 exons (NM_007275; Lerman and Minna, 2000). Overexpression of the FUS1 gene leads to G1 arrest and growth inhibition of lung cancer cells (Kondo et al., 2001). The human and the murine FUS1 genes were assigned to chromosome HSA3p21.3 a...
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The human LHX1 gene encodes a protein that is a member of the LIM family of homeodomain proteins. LHX1 was originally cloned as an apparent homologue of the mouse Lhx1 gene and mapped to human chromosome 11p13→p12 (Dong et al., 1997). In the mouse, the Lhx1 gene is expressed in the developing kidney, and portions of the CNS where it is believed to be an essential regulator of the vertebrate hea...
متن کاملPhysical Mapping by STS Hybridization :
An important tool in the analysis of genomic sequences is the physical map. In this paper we examine the construction of physical maps from hybridization data between STS (sequence tag sites) probes and clones of genomic fragments. An algorithmic theory of the mapping process, a proposed performance evaluation procedure, and several new algorithmic strategies for mapping are given. A unifying t...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1991
ISSN: 0754-0264
DOI: 10.1051/gse:19910737